Kane could be out for rest of the season, says Pochettino

Kane appeared to roll his left ankle in a coming-together with City’s Fabian Delph and was replaced by Lucas Moura in the 58th minute.

He was helped down the tunnel with the score still at 0-0.

Son Heung-min put Spurs ahead in the 78th minute and they held on to win the match 1-0, putting themselves in pole position with the second leg of the quarter-final to come in Manchester on April 17.

“It’s very, very sad. It’s going to be tough and we’re going to miss him — maybe for the rest of the season,” Tottenham’s Argentine coach told BT Sport.

Spurs goalkeeper Hugo Lloris said he did not know the full extent of Kane’s injury.

“Hopefully it is not too bad,” Lloris said. “I don’t know. You know the feeling when one of your best players is going off the field.

“But we stayed strong and we finished the game in the right way.”

Kane, who injured ligaments in his left ankle during Tottenham’s Premier League defeat against Manchester United on January 13, only returned in late February, missing seven matches.

It was the third successive season the Spurs talisman has missed games due to an ankle injury.

The 25-year-old, the winner of the Golden Boot at last year’s World Cup, has scored 27 goals for club and country this season.

Tottenham are fourth in the Premier League, chasing a Champions League place for next season.

England boss Gareth Southgate will also be concerned, with the Nations League Finals looming.