Napoli, who host Lazio in Serie A on Saturday, said in a statement that Ghoulam “injured his right knee during the team’s training session” on Friday, and a fractured patella was suspected.
“Ghoulam will be visited today by Professor Mariani at Villa Stuart (Sport Clinic in Rome),” the statement added.
It is the second injury for the 27-year-old this season after he suffered an anterior cruciate ligament rupture playing in the Champions League group-stage against Manchester City last November.
The France-born player was operated on by Professor Pier Paolo Mariani in November and was out of action for two months, only rejoining to team training just over a week ago.
It had been hoped that Ghoulam would make his eagerly-anticipated return when Napoli host Lazio on Saturday night.
Napoli are just one point ahead of Juventus with the six-time defending champions, who travel to Fiorentina on Friday night, looking to pull ahead.
Despite his injury Ghoulam recently signed a contract extension with Napoli.
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