The 29-year-old moved to Turin in August on a loan deal from German outfit Schalke 04 where he had spent his entire club career.
But he picked up a left thigh injury in training during the week ahead of the club’s Turin derby win over Torino.
“I imagined the start differently. I am extremely disappointed,” Hoewedes wrote on Twitter.
“Hoewedes sustained a thigh strain in his left leg affecting an area of scar tissue from a previous injury,” the six-time successive Serie A champions said.
It is estimated that the 44-times capped German international will be out of action for four weeks.
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