The club from outside Naples also confirmed they had fired sporting director Salvatore Di Somma before they travel to Cagliari midweek looking for their first points.
De Zerbi — a former midfielder with AC Milan and Napoli — previously coached Palermo for two months last season.
The 38-year-old’s stint with the Sicilians however ended in November 2016 after seven consecutive defeats and no points at home.
He was dismissed after the former Serie A side were eliminated from the Italian Cup by second-tier outfit Spezia.
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