The centre-back, who has a long history of calf problems, sustained the injury after completing the 90 minutes of Belgium’s 4-0 victory over Gibraltar in World Cup qualifying last week.
“He played with Belgium against Gibraltar. They won 9-0. He had a little problem in his calf. I think he will not be able (to play) tomorrow,” Guardiola told reporters at City’s training centre in Manchester.
Guardiola predicted that Kompany would only be sidelined for a “short” period of time.
City are level on points with second-placed Liverpool in the Premier League table after winning two and drawing one of their three games to date.
Download our app and read this and other great stories on the move. Available for Android and iOS.
