The centre-back, who has a long history of calf problems, sustained the injury after completing the 90 minutes of Belgium’s 4-0 victory over Gibraltar in World Cup qualifying last week.
“He played with Belgium against Gibraltar. They won 9-0. He had a little problem in his calf. I think he will not be able (to play) tomorrow,” Guardiola told reporters at City’s training centre in Manchester.
Guardiola predicted that Kompany would only be sidelined for a “short” period of time.
City are level on points with second-placed Liverpool in the Premier League table after winning two and drawing one of their three games to date.
