La Liga leaders Barcelona are bidding for a fifth successive Cup crown after crushing Sevilla 5-0 in last season’s final and face a Levante outfit sitting sixth in the Spanish top flight.
Aletico Madrid will take on Girona, while Sporting Gijon, the only second-tier side still in the competition, face Valencia.
Real play Leganes, who stunned the 13-time European champions on away goals in the quarter-finals last term.
Copa del Rey last-16 draw:
Getafe v Real Valladolid, Real Betis v Real Sociedad, Levante v Barcelona, Athletic Bilbao v Sevilla, Sporting Gijon v Valencia, Girona v Atletico Madrid, Villarreal v Espanyol
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