The Chilli Boys edged Bloemfontein Celtic 1-0 in the previous round of the competition and will be hoping to go further in the TKO by defeating Sundowns.
The Brazilians handed AmaZulu a 5-0 drubbing in the previous round of the TKO.
Sundowns, who are three-time champions in the Telkom Knockout, last won the competition in 2015.
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