Dybala scored twice in the first 22 minutes for the Italian champions and Giorgio Chiellini made it 3-0 10 minutes into the second half, leaving Barcelona shellshocked.
Having overturned a 4-0 first-leg deficit against Paris Saint-Germain in the last 16 by winning the return 6-1, Barcelona will need another stunning comeback in next week’s second leg if they are to reach the last four.
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