Pirates will play without the services of Thandani Ntshumayelo after the midfielder picked up a second yellow card in the first leg. His first booking was in the semi-final clash against Al Ahly.
His second yellow card means he will watch the game from the stands.
Ntshumayelo will be joined by Etoile du Sahel duo, Ghazi Abderrazak and Mohamed Amine Ben Amor, who were also cautioned in the first leg at Orlando Stadium. Amor was booked for a foul on Thamsanqa Gabuza.
Abderrazak will be replaced by Marouane Tej at left back for the clash in Sousse. Tej is available for this clash after serving his suspension.