AmaZulu won 1-0 at home to Witbank Spurs, while Moroka Swallows went down 2-0 at Cape Town All Stars.
Black Leopards who made it to the promotion playoffs at the end of last season, completed a 2-0 win over Milano United.
In a five-goal affair, African Warriors edged FC Cape Town 3-2. That would not be the highest scoring match of the opening round, however, as Mbombela United and Thanda Royal Zulu played out to a scintillating 3-3 draw.
In the final match of the day, Highlands Park drew 1-1 with Royal Eagles.