The first game between Maritzburg United and Bidvest Wits will kick-off the straight after the international break on Friday 18 at the Harry Gwala Stadium.
Kaizer Chiefs and Orlando Pirates managed to avoid each other in the first round when they were drawn against Stellenbosch FC and Cape Town City respectively.
Defending champions Baroka FC will play against reigning MTN 8 champions SuperSport United.
FRIDAY, OCTOBER 18
Maritzburg United vs Bidvest Wits – 8pm (Harry Gwala Stadium)
SATURDAY, OCTOBER 19
Cape Town City vs Kaizer Chiefs – 3pm (Cape Town Stadium)
Golden Arrows vs Polokwane City – 3pm (Sugar Ray Xulu Stadium)
Orlando Pirates vs Stellenbosch FC – 6pm (Orlando Stadium)
SuperSport United vs Baroka FC – 8.15pm (Lucas Moripe Stadium)
SUNDAY, OCTOBER 20
Mamelodi Sundowns vs Amazulu – 3pm (Lucas Moripe Stadium)
Highlands Park vs Black Leopards – 3pm (Makhulong Stadium)
TUESDAY, OCTOBER 22
Chippa United vs Bloemfontein Celtic – 7.30pm (Sisa Madukashe Stadium)