The club from Mediterranean industrial city Sfax received a bye into the round of 32, where they will face Paradou AC of Algeria or CI Kamsar of Guinea during September.
Paradou are the likelier winners of the preliminary tie next month, but as newcomers to CAF football they may lack the experience to eliminate Sfaxien over two legs.
The only local-based footballer in the Algeria squad that won the Africa Cup of Nations this month was Paradou midfielder Hicham Boudaoui, at 19 the youngest in the national squad.
Sfaxien have won the African version of the UEFA Europa League a record three times, beating big-name opponents in each final.
They overcame Al Merrikh of Sudan 5-2 overall in 2007, edged Etoile Sahel of Tunisia on away goals a year later and TP Mazembe of the Democratic Republic of Congo 3-2 in 2013.
Last season, coached by former Dutch star Ruud Krol, Sfaxien seemed set to reach the 2019 final after building a 2-0 semi-final first leg lead over Moroccan visitors Renaissance Berkane.
But, in a rare collapse by a Tunisian club in a CAF competition, they crashed 3-0 away and were eliminated.
– Challenge –
Krol has since departed, leaving Montenegrin Nebojsa Jovovic with the challenge of bringing the Confederation Cup trophy back to eastern Tunisia.
Sfaxien are the lone entrant among 53 challenging for a $1.25 million (1.12 mn euros) first prize to have won the Confederation Cup, which was introduced in 2004.
The other two CAF title winners are Enugu Rangers of Nigeria and Daring Club Motema Pembe of DR Congo.
Both lifted the now defunct African Cup Winners Cup: Enugu in 1977 and Motema Pembe in 1994.
Kinshasa-based Motema Pembe meet Stade Renard Melong of Cameroon, one of 19 Confederation Cup debutants, in a preliminary tie.
Enugu received a bye to the round of 32 where they await the winners between AS Pelican of Gabon and AS Maniema Union of DR Congo.
Mogadishu City Club will become the first Somali side to play in the Confederation Cup when they meet Malindi of Zanzibar, leaving Cape Verde and Eritrea as the only nations never to enter.
But the chances of Mogadishu winning the tie will be lessened by having to play their home match outside the country for security reasons with Djibouti City the probable venue.
The 2019/2020 CAF Confederation Cup preliminary round and last-32 draws:
ASC Snim (MTN) v ESAE (BEN)
US Gendamerie Nationale (NIG) v Al Ittihad (LBA)
Maranatha (TOG) v LISCR (LIB)
AS Pelican (GAB) v AS Maniema Union (COD)
Paradou AC (ALG) v CI Kamsar (GUI)
Bolton City (MRI) v Jwaneng Galaxy (BOT)
Mogadishu City (SOM) v Malindi (ZAN)
Akonangui (GEQ) v Ashanti Gold (GHA)
Niger Tornadoes (NGR) v Santoba (GUI)
TS Galaxy (RSA) v Saint Louis Suns Utd (SEY)
Buildcon (ZAM) v Young Buffaloes (SWZ)
AS Arta (DJI) Al Khartoum (SUD)
DC Motema Pembe (COD) v Stade Renard Melong (CMR)
AS Kigali (RWA) v Kinondoni Municipal Council (TAN)
Proline (UGA) v Masters Security (MAW)
Bandari (KEN) v Al Ahly Shendi (SUD)
US Ben Guerdane (TUN) v Amarat Utd (SSD)
Fasil Kenema (ETH) v Azam (TAN)
Triangle Utd (ZIM) v Rukinzo (BDI)
Pyramids (EGY) v Etoile (CGO)
CR Belouizdad (ALG) v AS CotonTchad (CHA)
First legs: Aug 9-11, second: Aug 23-25
Snim/ESAE v Salitas (BUR)
Gendamerie/Ittihad v Hassania Agadir (MAR)
Maranatha/LISCR v Djoliba (MLI)
Pelican/Maniema v Enugu Rangers (NGR)
Paradou/Kamsar v CS Sfaxien (TUN)
Bolton/Jwaneng v Zanaco (ZAM)
Mogadishu/Malindi v Al Masry (EGY)
Akonangui/Ashanti v Renaissance Berkane (MAR)
Tornadoes/Santoba v San Pedro (CIV)
Galaxy/Louis v CNaPS Sport (MAD)
Buildcon/Buffaloes v Bidvest Wits (RSA)
Arta/Khartoum v Pembe/Melong
Kigali/Kinondoni v Proline/Masters
Bandari/Shendi v Guerdane/Amarat
Kenema/Azam v Triangle/Rukinzo
Pyramids/Etoile v Belouizdad/CotonTchad
First legs: Sept 13-15, second: Sept 27-29
Note: winners qualify for playoffs against CAF Champions League last-32 losers