Mendy, 27, left Egypt on Tuesday to return to France for treatment on a broken left finger suffered during the warm-up ahead of Senegal’s 3-0 victory over Kenya in their final group game.
He was replaced in goal by Alfred Gomis of Italian club SPAL. Mendy’s injury comes as a big blow to a fancied Senegal side looking to win the Cup of Nations for the first time.
They face Uganda in the last 16 in Cairo on Friday, while Reims will hope to have Mendy back fit for the start of the Ligue 1 season against Marseille on August 10.
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