Images aired on national television showed the Pakistan International Airlines (PIA) flight had smashed into a residential area, with clouds of thick black smoke billowing from the site.
“The plane crashed in Karachi. We are trying to confirm the number of passengers but initially it is 99 passengers and eight crew members,” said Abdul Sattar Khokhar, the spokesman for the country’s aviation authority, adding that the flight was coming from Lahore.
Khokhar added that the aircraft was an Airbus A320 and was en route to Karachi.
The Pakistan military later tweeted that security forces had been deployed to the area and helicopters were being used to survey the damage and help ongoing rescue operations.
It comes just days after the country began allowing commercial flights to resume after planes were grounded during a lockdown over the coronavirus pandemic.
Pakistan has a chequered military and civilian aviation safety record, with frequent plane and helicopter crashes over the years.
In 2016, a Pakistan International Airlines plane burst into flames after one of its two turboprop engines failed while flying from the remote northern to Islamabad, killing more than 40 people.
PIA, one of the world’s leading airlines until the 1970s, now suffers from a sinking reputation due to frequent cancellations, delays and financial troubles. It has been involved in numerous controversies over the years, including the jailing of a drunk pilot in Britain in 2013.
The crash comes as Pakistanis across the country are preparing to celebrate the end of Ramadan and the beginning of Eid al-Fitr, with many travelling back to their homes in cities and villages.
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