Fifty other warrants will be delivered to Interpol for IS suspects abroad, Siddiq al-Sour told a news conference, adding that the list was compiled after questioning of suspected IS members in several Libyan towns.
IS fighters have redeployed in the south of the country since the jihadist group was evicted from its bastion of Sirte on the Mediterranean coast last December after several months of heavy clashes.
Sour said their leaders were Libyan nationals but the rank-and-file came from neighbouring Tunisia, Egypt and Sudan.
In Sirte, officials were still working to identify the bodies of 780 dead IS fighters being kept in morgues, while dozens of other corpses remained under the rubble.
Libya has been rocked by chaos since the 2011 fall and killing of longtime dictator Moamer Kadhafi in a NATO-backed revolution.
Jihadists, arms dealers and people traffickers have gained a foothold in the North African country as multiple authorities and dozens of militias vie for power.
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