Prop Jacques van Rooyen will start ahead of CJ van der Linde, while hooker Robbie Coetzee has been promoted to the starting line-up ahead of Willie Wepener.
Lions Under-21 lock Ruan Venter will receive a starting berth in the place of Willie Britz, who shifts back into a loose-forward position.
Flanker Jaco Kriel has been given a place in the starting line-up, with Warwick Tecklenberg providing cover off the bench.
In the backline, Tian Meyer will start at scrumhalf, while Ross Cronje will be the backup.
Andries Coetzee will start on the wing in the place of Deon Helberg, who was named among the replacements.
Lions team: Jacques van Rooyen, Robbie Coetzee, Ruan Dreyer, Ruan Venter, Franco van der Merwe, Jaco Kriel, Derick Minnie (captain), Willie Britz, Tian Meyer, Elton Jantjies, Anthony Volmink, Dylan Des Fountain, Robert de Bruyn, Andries Coetzee, Marnitz Boshoff. Replacements: Willie Wepener, CJ van der Linde, JJ Breet, Warwick Tecklenberg, Ross Cronje, Deon Helberg, Ruhan Nel.