The Junior Boks were the top seeded team in Pool B and will come up against Australia, Samoa and Italy from June 2 to 20.
“The format of the competition demands that you will have to be on your very best in each match. Italy will play with a lot of passion and commitment in front of their home fans, so that will be tough opener for us,” Junior Springbok coach Dawie Theron said in a statement.
“Samoa showed in their match against us in New Zealand that they are a very difficult team to beat, while Australia are a well-organised side and will no doubt have several players with Super Rugby experience in their squad.”
Pool A consists of England — who return to defend their title — France, Wales and Japan while New Zealand, Ireland, Argentina and Scotland were grouped in Pool C.
In other opening-day matches, England will play Japan, who return to the U20 competition for the first time since 2009, and four-time winners New Zealand take on Scotland.