To follow every moment of the game LIVE, click or tap on THIS LINK!
United will be desperate to bounce back from a recent run of form that has seen them lose six of their last eight games across all competitions, a run that includes Sunday’s 4-0 hammering at Everton.
City, by contrast, have won 10 Premier League matches on the spin since losing at Newcastle at the end of January, and they can move back to the top of the Premier League standings if they secure all three points at the home of their city rivals.
That may be easier said than done, however, as, despite their poor recent form, United are actually unbeaten in their last 14 top-flight matches on home soil, winning nine of those games, with Tottenham being the last team to claim all three points at Old Trafford back in August.
However, if any team knows how to win at the Theatre of Dreams it is City, who have emerged victorious on five of their last seven league trips to Old Trafford, including a 2-1 victory on their most recent visit last season.
United boss Ole Gunnar Solskjaer was involved in many Manchester derbies as a player, but this will be his first one as a manager and he is expected to be boosted by the return of midfielder Ander Herrera, who has been sidelined for the last four weeks with a thigh injury.
For more news your way, download The Citizen’s app for iOS and Android.
Download our app and read this and other great stories on the move. Available for Android and iOS.