Ackermann brought in Martin Muller, at lock, for the injured Franco van der Merwe.
In the backline, the former Springbok made a double change, bringing in Andries Coetzee, who starts at fullback, with Lionel Mapoe coming into the starting XV at outside centre.
As a result, Deon van Rensburg shifts to wing.
Meanwhile on the bench, Malcolm Marx is set to make his Super Rugby debut while Warwick Tecklenburg and Elton Jantjies are also two new inclusions for Saturday’s fixture.
Lions team: Andries Coetzee, Deon van Rensburg, Lionel Mapoe, Stefan Watermeyer, Courtnall Skosan, Marnitz Boshoff, Faf de Klerk, Warren Whiteley (Captain), Willie Britz, Jaco Kriel, Martin Muller, Franco Mostert, Julian Redelinghuys, Willie Wepener, Schalk van der Merwe.
Replacements: Malcolm Marx, Corne Fourie, Ruan Dreyer, MB Lusaseni, Warwick Tecklenburg, Ross Cronje, Elton Jantjies, JW Jonker.