Golden Lions head coach Russell Winter has named his 22-man side to take on the Griffons at Bill Jardine Stadium on Saturday March 29.
The match will kick off at 16:00.
Winter has opted to rest several players for the Vodacom Cup round four clash.
In the forwards, both Sephatho Qinisile and Nico du Plessis have moved up into the starting line-up.
Meanwhile, in the Golden Lions backline, Willie du Plessis has reclaimed the number ten jersey, while Kobus de Kock, JR Esterhuizen and Ruhan Nel all move into the starting XV.
The team is:
15. Ruhan Nel
14. JR Esterhuizen
13. Stokkies Hanekom
12. Kobus de Kock
11. Vainon Willis
10. Willie du Plessis
9. Ricky Schroeder (c)
8. Ruaan Lerm (vc)
7. Cyle Brink
6. Thabo Mabuza
5. Hugo Kloppers
4. Chris van Zyl
3. Nico du Plessis
2. Sephatho Qinisile
1. Charles Marais
16. Ashley Kohler
17. Tyson Mulamba
18. Lourens Erasmus
19. Lambert Groenewald
20. Guy Cronje
21. Brendon Hewitt
22. Caswell Khoza
Bogeys, favourites and defending champions
Meanwhile three South African sides will be in action in the Vodacom Super Rugby over the weekend while the Lions will have a bye.
An Australian bogey side and an Aussie favourite, as well as the defending champions from New Zealand are awaiting the three South African Vodacom Super Rugby sides in action on Saturday.
With two local sides enjoying breaks this weekend, round seven kicks off from a South African point of view with the DHL Stormers’ final tour match, in Brisbane against the Reds, the Aussie side against which the Capetonians boast the best winning percentage.
Thereafter the Vodacom Bulls will face the defending champions, the Chiefs from New Zealand, in a rare 15:00 match in Pretoria. The last time a match kicked off this early at Loftus Versfeld, was last year’s semi-final against the Brumbies, and before that in 2010.
In the final match of the weekend, the Cell C Sharks will be looking to bounce back when they are back at Growthpoint Kings Park against the Waratahs, which is their bogey team from Australia.
Two South African sides, the Lions and the Toyota Cheetahs, have a bye this weekend, along with the Force.
Other fixtures (South African kick-off times):
Saturday March 22:
08:35: Blues v Highlanders – Auckland
Byes: Lions, Toyota Cheetahs, Force