The Legal Resources Centre said the anti-apartheid activist died peacefully at home of natural causes, attended to by his family.
The renowned human rights activist and lawyer died at the age of 92.
Bizos represented the late former South African President Nelson Mandela at his treason trial in 1963.
In a Tweet last night President Cyril Ramaphosa said the news of the passing of George Bizos is very sad for us as a country.
Ramaphosa described Bizos as an incisive legal mind and architect of our Constitution
βHe contributed immensely to our democracy. We extend our deepest condolences to his family and dip our heads in his honour.β
According to SA History Online Bizos appeared at the Truth and Reconciliation Commission (TRC), representing families of liberation heroes such as Steve Bantu Biko, Chris Hani and the Cradock Four.
The Ahmed Kathrada Foundation is saddened by the news that veteran human rights lawyer George Bizos has passed away π
Lala ngoxolo #GeorgeBizos pic.twitter.com/oYJKgM0ViV
— Kathrada Foundation (@KathradaFound) September 9, 2020
He fought a good fight in pursuit of a Just South Africa that belongs to all who live in it. Sad to see this resolute social justice and integrity crusader go to join Madiba and his other compatriots. Heartfelt Condolences to the family, friends and colleagues #RIPGeorgeBizos pic.twitter.com/XrmfZi85Cc
— Prof Thuli Madonsela #KindnessBuilds (@ThuliMadonsela3) September 9, 2020
Aaah! George Bizos. How many lives you touched. Your mark on the map to Freedom is indelible. South Africa's history can NEVER be told without the echoes of your chant for freedom, justice and democracy. You are a giant tree that will never, ever fall. Rest easy. And thank you pic.twitter.com/8tyXXsAgJE
— Redi Tlhabi (@RediTlhabi) September 9, 2020
We have lost a legend. Deeply saddened to hear of the passing of Human Rights Advocate George Bizos. South Africa owes you a debt of gratitude.
May you rest in eternal peace.#RIPGeorgeBizos pic.twitter.com/MaQ2QGesR4
— Herman Mashaba (@HermanMashaba) September 9, 2020