Sanele Goodness May, 23, from Swaziland, was arrested on September 6 on 22 counts of murder and one of reckless or negligent driving.
Magistrate Wendolynn Robinson postponed the case to Monday, but said a formal bail application would take place on September 18.
Defence attorney Theasen Pillay confirmed that he had been appointed by Sagekal Logistics, the company which owned the truck, to represent May.
May was initially charged with culpable homicide, but National Prosecuting Authority spokeswoman Natasha Ramkisson confirmed that the charges had been upgraded to murder.
The accident occurred when the articulated truck hit four fully-laden minibus taxis and a Volkswagen Golf on the corners of Fields Hill (M13) and Richmond roads in Pinetown shortly before 7pm on September 6.
KwaZulu-Natal Health MEC Sibongiseni Dhlomo said the death toll was now at 23, after one of those injured in the accident died in hospital on Saturday morning.