Police spokesman Major Thulane Zwane said the first arrest at the border post shortly before midday on Tuesday resulted in the seizure of cocaine worth R800,000 from a Mozambican national.
The cocaine was stashed in a secret compartment in his bag.
Later in the afternoon, the driver of a tanker was arrested after he was found in possession of dagga with an estimated street value of R5,500.
And then shortly before 10pm, a Swazi national was arrested as he attempted to bring in dagga with an estimated street value of R8,100.
Zwane said the three men were expected to appear in court soon.