The man was found lying in the middle of the road in a critical condition, said ER24 spokesman Werner Vermaak.
The man died shortly after his arrival at Chris Hani Baragwanath hospital, despite resuscitation efforts, said Vermaak.
The driver of the vehicle did not sustain any visible injuries.
He was treated for shock on the scene before being transported to another hospital.
“The incident was handed over to Johannesburg metro police for further investigation,” said Vermaak.