“Violence can never be condoned at a protest action, by either side,” North West Democratic Alliance leader Chris Hattingh said in a statement on Monday.
Two protesters were shot dead and two were wounded during a service delivery protest, said Colonel Sabata Mokgobone.
Police were called to monitor protesters after they barricaded a road with burning tyres.
Hattingh said the party was shocked and outraged at the incident.
Residents of Letlhabile have been without water for a week.
Details of the shooting were not clear, Mokgobone said.