The 2007 IRB Player of the Year had been picked in the original Team South Africa squad but according to a statement released by SASCOC, he will not take part in the competition as he missed the selection deadline.
The 31-year-old has had a great year with Toulon, winning the French Top 14 Championship and the Heineken Cup with the club, but will be unable to add a Commonwealth gold medal to the list should the Blitzbokke go that far.
The Sevens squad plays three matches on Saturday, against Trinidad & Tobago, the Cook Islands and Kenya, before the knockout matches and medal games on Sunday.
SA Sevens squad: Chris Dry, Kwagga Smith, Frankie Horne, Warren Whiteley, Cornal Hendricks, Kyle Brown, Branco du Preez, Mark Richards, Justin Geduld, Cecil Afrika, Werner Kok and Seabelo Senatla.