The road carnage flared up on Friday evening with Traffic Alert reporting a collision between two vehicles on the N11 (Loskop) a short distance out of Middelburg.
Emergency services were dispatched to attend to the injured.
Motorists were also warned of a stationary truck blocking off part of the lane on the N11 just passed Doornkop.
A single motor vehicle was reported early this morning on the R575 Dhuva, resulting in the driver being rushed to hospital.
A collision between trucks resulted in the closure of the road entering Bethal from the R35 at roughly 07:00 this morning.
Caution was also advised to motorists traversing the N4 between Wonderfontein to Mbombela as heavy mist affected visibility this morning.
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