Mkwaiwa died on his way to hospital near Bronkhorstspruit in Mpumalanga on Sunday night after reportedly complaining about a fever, Destiny Man reported.
He leaves behind his wife Tina Mkwaiwa and his children with film and television actress Tina Jaxa.
In the past, Mkwaiwa has also been romantically linked with controversial afro-pop singer Kelly Khumalo.
His death comes after popular Top Billing presenter Simbarashe ‘Simba’ Mhere died in a car accident on Saturday morning.
Mhere was reportedly driving on William Nicol Drive when a A VW Polo crossed over the middle island and crashed into his side.
Mhere and one passenger died on the scene. A third passenger in the car and the VW Polo driver were taken to hospital.
Meanwhile on Twitter, tributes continue to pour in for Mkwaiwa:
My heart goes out to one of my best friends/sister Tina Dlangwana/Mkwaiwa & Farrai on the loss of Prosper, I actually still can't believe
— Kamo_Phajane (@RealKazMic) February 2, 2015
— IG: Clifford_Masinga (@CliffordMP) February 1, 2015
Thank u Prosper for believing in 3SUM and giving us a chance #RIP MrPro mkwaiwa
— Amstel (@AmstelDiva) February 1, 2015
Prosper Mkwaiwa is no more… Kante what is going on guys? Wehhhhh. Death be not proud.
— Thenjiwe Khumalo (@10GEE_Khumi) February 1, 2015
— Tash* (@ForeverTash_) February 2, 2015
— Thapelo Moloko (@Molocco_T) February 2, 2015