According to information, two vehicles entered the SASOL Garage at around 03:00 this morning.
Between 6 and 9 heavily armed suspects entered the premise, Letaba Herald was told.
The bombing comes a week after the Total Bonjour Café was bombed on Sunday February 4.
Read: PHOTOS: Safe bombed inside Bonjour Cafè
Stopper groups were put in place to deal with any vehicles that wanted to interrupt the suspects.
Read: [WATCH] Two Polokwane fuel stations targeted in attempted safe bombings
The safe was blown up and an undisclosed amount of money was taken.
The suspects fled in a white BMW and a Silver Toyota Conquest.
No injuries were sustained during the robbery.
Read: Manhunt launched for suspects involved in Polokwane petrol station bombings
All emergency personnel were on scene.
SAPS are still busy on the scene.