Luthando Evidence Mbalo (29), from Buhle Park, was reported missing by his father, Samson Mbalo, at the Germiston Police Station on May 22.
Samson told the police that he had last seen Luthando at the Gosforth Park toll plaza on May 21, between 7pm and 8pm.
His son had allegedly run from Johannesburg, possibly along the highway towards Germiston.
The information he received was that his son had allegedly not looked well and that an ambulance had been arranged for him.
However, when the ambulance arrived, his son was no longer there.
Enquiries thus far at hospitals and the area surrounding the toll plaza have been conducted to no avail.
Luthando was wearing grey Nike track pants and had grey Diesel running shoes on at the time of his disappearance.
He is described as having an athletic build.
Anyone with information can call Samson on 078 341 0279 or Lieut-Col Andy Pieke at the Germiston Police Station on 011 871- 5025.
The National Missing Persons Bureau can also be contacted on 08600 10111.
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