The accident happened near the Putfontein turn-off, when travelling towards Johannesburg, at about 3pm.
ER24 spokesperson Clair Wolstencroft said one of the vehicles overturned.
A man in this car sustained moderate injuries and was transported to Sunshine Hospital.
Three other people in the same car had minor injuries and they were taken to Tambo Memorial Hospital.
The four people in the second vehicle were not injured.
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