The incident happened between Elizabeth Road and Rolls Royce Street at about 10.30am.
ER24 spokesperson, Liam Hardy, said there were three men involved in the single vehicle crash.
The driver was entrapped and was later transported to Life the Glynnwood Hospital.
The remaining occupants sustained minor to moderate injuries.
They were taken to the Sunshine Hospital.
Also read:
Pedestrian critically injured near Putfontein off-ramp
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