Emirates Lions will have a face-off with the Highlanders as they host them on home soil on Saturday.
Warren Whiteley will once again not be in the Lions squad due to a bruised knee, while the captaincy will be taken over from him by Springbok hooker Malcolm Marx.
The local franchise will play their Vodacom Super Rugby clash against the Highlanders on May 18 at 3.05pm. The gates open at 11am.
Emirates Lions coach Swys de Bruin also announced changes to the loose trio and front row from the team that beat the Waratahs last weekend.
Dylan Smith comes in for Sti Sithole at loosehead prop, while Kwagga Smith moves from flank to number eight in the absence of Whiteley. Marnus Schoeman takes over the number six jersey duties from Smith, while Cyle Brink will don the number seven jersey in place of Vincent Tshituka.
The Highvelders held on to a nail-biting 29-28 win over a Waratahs side in Joburg and they will have to deliver an improved effort if they want to topple the Highlanders. The Pride of Jozi need a good performance if they want to keep alive their play-off hopes.
Looking at the history of previous games between the two sides, then both teams have won six times in the 12 fixtures between them to date. Interestingly, each side were alternate winners in the last 10 times they have faced each other.
The Vodacom Bulls will be determined to get back on the winning track when they face the Rebels in the first game of their four-match Vodacom Super Rugby tour to Australasia in Melbourne on Friday morning at 11.45am (SA time), while a local double-header awaits on Saturday afternoon.
In Cape Town, the DHL Stormers face the Crusaders in a very important clash at DHL Newlands, where the kick-off is 5.15pm.
The Cell C Sharks have a bye this weekend, while the Jaguares – the other team in the SA Conference – square up to the Hurricanes in Wellington on Friday morning.
Other matches in Round 14:
May 4
9.35am: Blues v Chiefs, Eeden Park, Auckland
11.45am: Reds vs Waratahs, Suncorp Stadium, Brisbane
Byes: Brumbies, Sharks, Sunwolves.
