According to The Guardian, Mikel recently underwent surgery and is currently recuperating in England and is in a race against time to be fit for the game.
The newspaper further reported that Eagles number-one goalkeeper Carl Ikeme and fellow goalie Vincent Enyeama are also both out on injuries.
Nigeria and Bafana are set to play at the Godswill Akpabio International Stadium in Uyo on June 10.
The two teams are in Group E of the 2019 Africa Cup of Nations qualifier alongside Libya and Seychelles.
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